FROM CELL INTERCALATION TO FLOW, THE IMPORTANCE OF T1 TRANSITIONS

From cell intercalation to flow, the importance of T1 transitions

From cell intercalation to flow, the importance of T1 transitions

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T1 transitions, also called cell intercalations, are important sources of fluidization of epithelial cell monolayers.We use a multiphase field model to quantify this tissue fluidization in terms of the relative dispersion of cells and characterize the T1 flow profile.We show that the ensemble-averaged flow profile of a Wide Seat Recliner with Power T1 transition has a saddle-point pattern accompanied by a localized burst in cell speed.

Although the temporal evolution of the relative dispersion of cells depends on specific model details, the different dispersion curves collapse robustly onto a linear function of the number of T1 transitions, implying an important Sleep Formulas connection between T1 transitions and mixing in dense systems.

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